Subjective-Objective Sleep Discrepancy is Associated with Alterations in Regional Glucose Metabolism in Patients with Insomnia and Good Sleeper Controls.

Subjective-Objective Sleep Discrepancy is Associated with Alterations in Regional Glucose Metabolism in Patients with Insomnia and Good Sleeper Controls.

Sleep. 2017 Oct 03;:

Authors: Kay DB, Karim HT, Soehner AM, Hasler BP, James JA, Germain A, Hall MH, Franzen PL, Price JC, Nofzinger EA, Buysse DJ

Abstract
Objectives: Sleep discrepancies are common in primary insomnia (PI), and include reports of longer sleep onset latency (SOL) than measured by polysomnography (PSG), or "negative SOL discrepancy." We hypothesized that negative SOL discrepancy in PI would be associated with higher relative glucose metabolism during non-rapid eye movement (NREM) sleep in brain networks involved in conscious awareness, including the salience, left executive control, and default mode networks.
Methods: PI (n=32) and good sleeper controls (GS; n=30) completed [ 18F]fluorodeoxyglucose positron emission tomography (FDG-PET) scans during NREM sleep and relative regional cerebral metabolic rate for glucose (rCMRglc) was measured. Sleep discrepancy was calculated by subtracting PSG-measured SOL on the PET night from corresponding self-report values the following morning. We tested for interactions between group (PI vs. GS) and SOL discrepancy for rCMRglc during NREM sleep using both a region of interest mask and exploratory whole-brain analyses.
Results: Significant group by SOL discrepancy interactions for rCMRglc were observed in several brain regions (pcorrected<0.05 for all clusters). In the PI group, more negative SOL discrepancy (self-reported>PSG-measured SOL) was associated with significantly higher relative rCMRglc in the right anterior insula and middle/posterior cingulate during NREM sleep. In GS, more positive SOL discrepancy (self-reported<PSG-measured SOL) was associated with significantly higher relative rCMRglc in the right anterior insula, left anterior cingulate cortex, and middle/posterior cingulate cortex.
Conclusions: Although preliminary, these findings suggest regions of the brain previously shown to be involved in conscious awareness and the perception of PSG-defined states may also be involved in the phenomena of SOL discrepancy.

PMID: 29029313 [PubMed - as supplied by publisher]

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