Sodium Restriction in Patients With CKD: A Randomized Controlled Trial of Self-management Support.

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Sodium Restriction in Patients With CKD: A Randomized Controlled Trial of Self-management Support.

Am J Kidney Dis. 2017 May;69(5):576-586

Authors: Meuleman Y, Hoekstra T, Dekker FW, Navis G, Vogt L, van der Boog PJM, Bos WJW, van Montfrans GA, van Dijk S, ESMO Study Group

Abstract
BACKGROUND: To evaluate the effectiveness and sustainability of self-managed sodium restriction in patients with chronic kidney disease.
STUDY DESIGN: Open randomized controlled trial.
SETTING & PARTICIPANTS: Patients with moderately decreased kidney function from 4 hospitals in the Netherlands.
INTERVENTION: Regular care was compared with regular care plus an intervention comprising education, motivational interviewing, coaching, and self-monitoring of blood pressure (BP) and sodium.
OUTCOMES: Primary outcomes were sodium excretion and BP after the 3-month intervention and at 6-month follow-up. Secondary outcomes were protein excretion, kidney function, antihypertensive medication, self-efficacy, and health-related quality of life (HRQoL).
RESULTS: At baseline, mean sodium excretion rate was 163.6±64.9 (SD) mmol/24 h; mean estimated glomerular filtration rate was 49.7±25.6mL/min/1.73m(2); median protein excretion rate was 0.8 (IQR, 0.4-1.7) g/24 h; and mean 24-hour ambulatory systolic and diastolic BPs were 129±15 and 76±9mmHg, respectively. Compared to regular care only (n=71), at 3 months, the intervention group (n=67) showed reduced sodium excretion rate (mean change, -30.3 [95% CI, -54.7 to -5.9] mmol/24 h), daytime ambulatory diastolic BP (mean change, -3.4 [95% CI, -6.3 to -0.6] mmHg), diastolic office BP (mean change, -5.2 [95% CI, -8.4 to -2.1] mmHg), protein excretion (mean change, -0.4 [95% CI, -0.7 to -0.1] g/24h), and improved self-efficacy (mean change, 0.5 [95% CI, 0.1 to 0.9]). At 6 months, differences in sodium excretion rates and ambulatory BPs between the groups were not significant, but differences were detected in systolic and diastolic office BPs (mean changes of -7.3 [95% CI, -12.7 to -1.9] and -3.8 [95% CI, -6.9 to -0.6] mmHg, respectively), protein excretion (mean changes, -0.3 [95% CI, -0.6 to -0.1] g/24h), and self-efficacy (mean change, 0.5 [95% CI, 0.0 to 0.9]). No differences in kidney function, medication, and HRQoL were observed.
LIMITATIONS: Nonblinding, relatively low response rate, and missing data.
CONCLUSIONS: Compared to regular care only, this self-management intervention modestly improved outcomes, although effects on sodium excretion and ambulatory BP diminish over time.

PMID: 27993433 [PubMed - indexed for MEDLINE]

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