Utilizing methylglyoxal and D-lactate in urine to evaluate saikosaponin C treatment in mice with accelerated nephrotoxic serum nephritis

als.fakia shared this article with you from Inoreader Utilizing methylglyoxal and D-lactate in urine to evaluate saikosaponin C treatment in mice with accelerated nephrotoxic serum nephritis Via PLOS ONE Alerts: New Articles by Chia-Yu Lin, Jen-Ai Lee, Po-Yeh Lin, Shih-Chun Hua, Pei-Yun Tsai, Bi-Li Chen, Chia-En Lin, Tzong-Huei Lee, Shih‐Ming Chen The relationship between methylglyoxal (MGO) and D-lactate during saikosaponin C (SSC) treatment of mice with accelerated nephrotoxic serum (NTS) nephritis was investigated. NTS nephritis was induced by administration of anti-basement membrane antibodies to C57BL/6 mice and three dosages of SSC were administered for 14 days. Proteinuria, blood urea nitrogen, serum creatinine, renal histology, urinary MGO and d-lactate changes were examined. Compared to the NTS control group, the middle dosage (10 mg/kg/day) of SSC significantly alleviated the development of nephritis based on urine protein measurements (34.40 ± 6.85 vs. 17.33 ± 4.79 mg/day, pppp View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.