β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration

β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration

β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration, Published online: 20 February 2019; doi:10.1038/s41586-019-0964-2

In a rat model of multiple sclerosis, β-synuclein-specific T cells induce inflammation and pathological changes in the grey matter of the central nervous system; these cells were also found in higher numbers in patients with multiple sclerosis, particularly those with a chronic progressive course.

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