Female-biased embryonic death from inflammation induced by genomic instability

Female-biased embryonic death from inflammation induced by genomic instability

Female-biased embryonic death from inflammation induced by genomic instability, Published online: 20 February 2019; doi:10.1038/s41586-019-0936-6

Genomic instability, caused by MCM mutations, results in embryonic lethality that disproportionally affects female mouse embryos and is rescued by testosterone or ibuprofen treatment, both of which ameliorate inflammatory effects.

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