Prostate Cancer Pulmonary Metastasis Presenting as a Ground-Glass Pulmonary Nodule on 68Ga-PSMA-11 PET/CT

68Ga–prostate-specific membrane antigen 11 (PSMA) PET/CT imaging accurately depicts metastatic prostate adenocarcinoma (PCa). Pulmonary metastases of PCa are often overlooked on follow-up imaging in patients after initial treatment and following androgen deprivation therapy. Here we present a rare case of biopsy-proven PCa pulmonary metastasis with a ground-glass appearance. The increased PSMA expression and the evolving CT features of the solid component of the ground-glass nodule detected by PSMA PET/CT imaging led to surgical resection and PET/CT-guided therapy. Received for publication November 14, 2018; revision accepted December 25, 2018. Conflicts of interest and sources of funding: J.C. is the recipient of a grant from the Philippe Foundation Inc (New York). None declared to all other authors. Author's contributions: Conception and design: S.H., R.R., M.R., C.K., and J.C.; Acquisition of data: D.L., J.M.L., C.K., W.D.W., and J.C.; Analysis and interpretation of data: S.H., R.R., M.R., C.K., W.D.W., and J.C.; Drafting/revising of the manuscript critically for important intellectual content: D.L., S.H., R.R., M.R., J.M.L., C.K., W.D.W., and J.C.; Final manuscript approval for submission and publication: D.L., S.H., R.R., M.R., J.M.L., C.K., W.D.W., and J.C. Correspondence to: Jeremie Calais, MD, MSc, Ahmanson Translational Imaging and Nuclear Medicine Division, Department of Molecular & Medical Pharmacology, University of California, Los Angeles, Peter Norton Medical Bldg, 200 Medical Plaza, Suite B-114-51, Los Angeles, CA 90095. E-mail: jcalais@mednet.ucla.edu. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

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