Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits

Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits

Microglia and amyloid precursor protein coordinate control of transient <i>Candida</i> cerebritis with memory deficits, Published online: 04 January 2019; doi:10.1038/s41467-018-07991-4

The potential links between infections and neurodegenerative disorders are unclear. Here, Wu et al. present a mouse model of low-grade candidemia characterized by highly localized cerebritis, accumulation of amyloid precursor protein and beta peptides, and mild memory impairment that resolves with fungal clearance.

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