Cu‐Mediated Aminoquinoline‐Directed Radiofluorination of Aromatic C–H Bonds with K¹⁸F

This communication describes a Cu‐mediated ortho‐C–H radiofluorination of aromatic carboxylic acids that are protected as 8‐aminoquinoline benzamides. The method uses K¹⁸F and is compatible with a wide range of functional groups. The reaction is showcased in the high specific activity automated synthesis of the RARβ2 agonist [¹⁸F]AC261066.

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