A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids

A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids

A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids, Published online: 04 January 2019; doi:10.1038/s41467-018-07898-0

CD1 proteins present lipid antigens to T cells via the T cell receptor. Here the authors describe T cell reactivity to human membrane lipid moieties and provide structural data to define a molecular mechanism of promiscuous recognition of self-derived phospholipids.

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