Discoidin-domain receptor coordinates cell-matrix adhesion and collective polarity in migratory cardiopharyngeal progenitors

Discoidin-domain receptor coordinates cell-matrix adhesion and collective polarity in migratory cardiopharyngeal progenitors

Discoidin-domain receptor coordinates cell-matrix adhesion and collective polarity in migratory cardiopharyngeal progenitors, Published online: 04 January 2019; doi:10.1038/s41467-018-07976-3

In Ciona, cardiopharyngeal progenitors migrate as polarized pairs of cells between the epidermis and the endoderm. Here the authors show that the endoderm secretes a particular collagen, which promotes Discoidin domain receptor activity to control cell-matrix adhesion and collective polarity.

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