Bioinspired Engineering of a Multivalent Aptamer‐Functionalized Nanointerface to Enhance the Capture and Release of Circulating Tumor Cells

An aptamer‐functionalized nanointerface for capture and release of circulating tumor cells (CTCs) is described by C. Yang et al. in their Communication (DOI: 10.1002/anie.201809337). Inspired by the prey capture mechanism of the octopus, an aptamer‐tailed octopus chip was engineered, which combines a multi‐valence effect to enhance binding affinity, size‐selective enhancement of cell–micropillar collisions to improve capture efficiency, and a thiol–gold interface for nondestructive release of CTCs for downstream analysis.

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