FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation

FGL2 promotes tumor progression in the CNS by suppressing CD103⁺ dendritic cell differentiation

FGL2 promotes tumor progression in the CNS by suppressing CD103⁺ dendritic cell differentiation, Published online: 25 January 2019; doi:10.1038/s41467-018-08271-x

Fibrinogen-like protein 2 (FGL2) mediates immune suppression in glioblastoma (GBM). Here, the authors show that FGL-2 expressed by GBM cancer cells acts by suppressing the differentiation of CD103+ DC cells required to activate the anti-tumor CD8+ T cell response via blocking GM-CSF signalling at NFKB, STAT1/5 and p38 level.

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