It takes two targets: A small‐molecule organic photothermal agent with two targeting ligands was designed to actively target tumor tissue and mitochondria and thus selectively kill cancer cells. The resulting antitumor agent (see structure) exhibited a high photothermal conversion efficiency of 37.8 %, low cytotoxicity, and good biocompatibility and showed excellent tumor inhibition in vivo.
Abstract
The development of highly effective anticancer drugs that cause minimal damage to the surrounding normal tissues is a challenging topic in cancer therapy. Herein, we demonstrate a dual‐targeted organic molecule that functions as a photothermal agent by actively targeting tumor tissue and mitochondria to selectively kill cancer cells. The synthesized photothermal agent exhibited high photothermal conversion efficiency, low cytotoxicity, and good biological compatibility. In vivo experiments showed an excellent tumor inhibitory effect of the dual‐targeted photothermal agent.
from A via a.sfakia on Inoreader http://bit.ly/2R6s9YU
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,