Structure of transcribing RNA polymerase II-nucleosome complex

Structure of transcribing RNA polymerase II-nucleosome complex

Structure of transcribing RNA polymerase II-nucleosome complex, Published online: 21 December 2018; doi:10.1038/s41467-018-07870-y

Eukaryotic transcription requires passage of RNA polymerase II (Pol II) through chromatin, which is impaired by nucleosomes. Here the authors report the cryo-EM structure of transcribing Pol II engaged with a downstream nucleosome core particle at an overall resolution of 4.4 Å, providing insights into the mechanism of chromatin transcription.

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