Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism

Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism

Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism, Published online: 21 December 2018; doi:10.1038/s41467-018-07868-6

Serine synthesis from glucose is required even when serine is available from the environment. Here, the authors explain this paradox by showing that the enzyme PHGDH enables nucleotide synthesis by coordinating anabolic fluxes related to central carbon metabolism, independent of its role in serine production.

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