Role of TGF- β in Self-Peptide Regulation of Autoimmunity

AbstractTransforming growth factor (TGF)- β has been implicated in regulation of the immune system, including autoimmunity. We have found that TGF-β is readily produced by T cells following immunization with self-peptide epitopes that downregulate autoimmune responses in type 1 diabetes (T1D) prone nonobese diabetic (NOD) mice. These incl ude multiple peptide epitopes derived from the islet β-cell antigens GAD65 (GAD65 p202-221, GAD65 p217-236), GAD67 (GAD67 p210-229, GAD67 p225-244), IGRP (IGRP p123-145, IGRP p195-214) and insulin B-chain (Ins. B:9-23) that protected NOD mice from T1D. Immunization of NOD mice with the self-MHC cla ss II I-Ag7β-chain-derived peptide, I-Aβg7 p54-76 also induced large amounts of TGF- β and also protected these mice from diabetes development. These res...

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