Managing metastatic bone pain: New perspectives, different solutions

Publication date: September 2017 Source:Biomedicine & Pharmacotherapy, Volume 93 Author(s): Iwona Zaporowska-Stachowiak, Jacek Łuczak, Karolina Hoffmann, Katarzyna Stachowiak, Wiesław Bryl, Maciej Sopata Bone metastases are the most frequent cause of cancer-induced bone pain (CIBP). Although palliative radiotherapy and pharmacotherapy conducted according to World Health Organization (WHO) analgesic ladder are the treatment of choice for CIBP reduction, these methods are not always successful, especially with regard to alleviation of incidental pain. Antiresorptive drugs (bisphosphonates) are able to inhibit bone destruction (loss), proliferation of cancer cells and angiogenesis, but their prolonged use may lead to a spectrum of adverse effects. In this paper, types of bone metas...

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