The lipopolysaccharide transport (Lpt) machinery: a non-conventional transporter for lipopolysaccharide assembly at the outer membrane of Gram-negative bacteria [Membrane Biology]

The outer membrane (OM) of Gram-negative is a unique lipid bilayer containing Lipopolysaccharide (LPS) in its outer leaflet. Because of the presence of amphipathic LPS molecules, the OM behaves as an effective permeability barrier that makes Gram-negative bacteria inherently resistant to many antibiotics. This review focuses on LPS biogenesis and discusses recent advances that have contributed to our understanding of how this complex molecule is transported across the cellular envelope and is assembled at the OM outer leaflet. Clearly this knowledge represents an important platform for the development of novel therapeutic options to manage Gram-negative infections.

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