Insulin resistance contributes to the development of diabetes and cardiovascular dysfunctions. Recent studies showed that elevated singlet oxygen-mediated lipid peroxidation precedes and predicts diet-induced insulin resistance (IR), and neutrophils were suggested to be responsible for such singlet oxygen production. This review highlights literature suggesting that insulin-responsive cells such as endothelial cells, hepatocytes, adipocytes, and myocytes also produce singlet oxygen, which contributes to insulin resistance, for example, by generating bioactive aldehydes, inducing endoplasmic reticulum (ER) stress, and modifying mitochondrial DNA. In these cells, nutrient overload leads to the activation of Toll-like receptor 4 and other receptors, leading to the production of both peroxynitrite and hydrogen peroxide, which react to produce singlet oxygen. Cytochrome P450 2E1 and cytochrome c also contribute to singlet oxygen formation in the ER and mitochondria, respectively. Endothelial cell-derived singlet oxygen is suggested to mediate the formation of oxidized low-density lipoprotein which perpetuates IR, partly through neutrophil recruitment to adipose tissue. New singlet oxygen-involving pathways for the formation of IR-inducing bioactive aldehydes such as 4-hydroperoxy-(or hydroxy or oxo)-2-nonenal, malondialdehyde, and cholesterol secosterol A are proposed. Strategies against IR should target the singlet oxygen-producing pathways, singlet oxygen quenching, and singlet oxygen-induced cellular responses.
from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2j54pVl
via IFTTT
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
Αρχειοθήκη ιστολογίου
-
►
2023
(272)
- ► Φεβρουαρίου (141)
- ► Ιανουαρίου (131)
-
►
2022
(2066)
- ► Δεκεμβρίου (80)
- ► Σεπτεμβρίου (170)
- ► Φεβρουαρίου (190)
- ► Ιανουαρίου (203)
-
►
2021
(7399)
- ► Δεκεμβρίου (186)
- ► Σεπτεμβρίου (472)
- ► Φεβρουαρίου (851)
-
►
2020
(2517)
- ► Δεκεμβρίου (792)
- ► Σεπτεμβρίου (21)
- ► Φεβρουαρίου (28)
-
►
2019
(12076)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (4765)
- ► Ιανουαρίου (5155)
-
►
2018
(3144)
- ► Δεκεμβρίου (3144)
-
▼
2017
(66935)
- ► Δεκεμβρίου (1995)
-
▼
Σεπτεμβρίου
(12424)
-
▼
Σεπ 06
(521)
- Table of Contents
- Table of Contents
- Editorial Board
- Editorial Board
- Guidelines for Contributing Authors
- Guidelines for Contributing Authors
- Risk Factors for Knee Injury in Golf: A Systematic...
- Histological Characteristics on the Testes of Mud ...
- The role of the transient receptor potential ankyr...
- Hypothesis Serum- and Glucocorticoid-inducible Kin...
- A comprehensive analysis on child mortality and it...
- Moscow dentistry seeks to aid those without insurance
- Helping cancer survivors return to work
- N-terminus determines activity and specificity of ...
- Erratum to: Clinical experience with four cases of...
- Acupuncture for temporomandibular joint syndrome
- Sclerosing thymoma-like thymic amyloidoma with nep...
- Zonnic®: a new player in an old field
- Free amino acids profile of Polish and Slovak hone...
- Culture broth of Ganoderma lucidum exhibited antio...
- Status of the bioactive phytoceuticals during deep...
- Safety, tolerability, and pharmacokinetic profile ...
- Effects of low-to-moderate alcohol supplementation...
- Long-term outcomes in patients treated with proton...
- Survival of cutaneous melanoma based on sex, age, ...
- Prognostic effect of parotid area lymph node metas...
- A Proposed Method for Identification of Streptomyc...
- A rational approach to enhancing antibody Fc homod...
- Structural basis for pH-insensitive inhibition of ...
- Enantiomeric barbiturates bind distinct inter- and...
- Lipid stress inhibits endocytosis of Melanocortin-...
- The lipopolysaccharide transport (Lpt) machinery: ...
- Identification of a 35S U4/U6.U5 Tri-snRNP Complex...
- Thioredoxin-1 actively maintains the pseudokinase ...
- Anxiety and pain related to mandibular block injec...
- Radiation-related caries assessment through the in...
- 23 year-old female with a painless left mandibular...
- AAOM clinical practice statement
- Mandibular embryonal rhabdomyosarcoma with cartila...
- Chronic lymphocytic leukemia with isochromosome 17...
- Role of cellular metabolism in regulating type I i...
- Discovery of peptide drug carrier candidates for t...
- mTOR signaling in immune cells and its implication...
- HSF1 upregulates ATG4B expression and enhances epi...
- Mutations of RNA splicing factors in hematological...
- TNF-related apoptosis-inducing ligand (TRAIL) for ...
- Organ- and cell-specific immune responses are asso...
- Proline-dependent and basophilic kinases phosphory...
- Identification of a new adtrp1-tfpi regulatory axi...
- The Rise of the Recliner as a Male Social Space
- The Rise of the Recliner as a Male Social Space
- Targeting Aberrant p70S6K Activation for Estrogen ...
- Alterations in bronchial airway microRNA expressio...
- An Essential Role of Maspin in Embryogenesis and T...
- An Essential Role of Maspin in Embryogenesis and T...
- Sudden sensorineural hearing loss in children and ...
- The Study of Calcium, Phosphonium, Magnesium, and ...
- Research and Clinical Application of Three-Dimensi...
- The Current Challenge for Plastic and Reconstructi...
- Intracranial Enterogenous Cysts Close to the Brain...
- Global Medical Cooperation With the East and West:...
- Three-Dimensional Radiologic Study on Index Measur...
- The Excellence of Graduate Medical Education in Ch...
- Eyelid and Periorbital Surgery, Second Edition, ed...
- Global Craniofacial Care
- Comprehensive Treatment of Primary Orbital Arterio...
- Meet Dr Kilner at the Hunterian Museum
- Relative Location of Fundus Meatus Acustici Intern...
- The Current Challenge For Plastic and Reconstructi...
- Role of Notch Signaling in the Physiological Patte...
- Intralesional Lidocaine Anesthesia: A Novel Facili...
- Three Skin Zones in the Asian Upper Eyelid Pertain...
- Reduction of Surgical Site Infections After Cranio...
- Single-Stage Reconstruction of Eyebrow Defect Usin...
- Comparison of Two Different Grafts in Nasal Framew...
- Oral Localization of Kaposi Sarcoma: Clinical Pres...
- Prognosis in patients with obstructive sleep apnea...
- Association of sleep duration and incidence of dia...
- Perceptual Differences between Novice and Professi...
- Commentary on: Treatment of laryngopharyngeal refl...
- Intraoperative imaging during minimally invasive t...
- Commentary on: Treatment of laryngopharyngeal refl...
- Intraoperative imaging during minimally invasive t...
- Acupuncture for temporomandibular joint syndrome
- Integra® as a single-stage dermal regeneration tem...
- Sudden sensorineural hearing loss in children and ...
- Sudden sensorineural hearing loss in children and ...
- American Brachytherapy Society recurrent carcinoma...
- The effect of breathing on ductus arteriosus blood...
- Comparing the Centering Ability of Different Pathf...
- A type of sleep therapy reduces depression, anxiet...
- Dealing with Chronic Illness: Experiences of Irani...
- Expression of C4.4A in an In Vitro Human Tissue-En...
- Impacts of Cloud Cover and Dust on the Performance...
- Static and Dynamic Mechanical Properties of Long-S...
- A Clustering Method for Isomorphic Evolution of We...
- Development of an Automatic Dispensing System for ...
- EE-eICIC: Energy-Efficient Optimization of Joint U...
- The Contribution of Singlet Oxygen to Insulin Resi...
- A Comparative Study of First-Order Reliability Met...
-
▼
Σεπ 06
(521)
Ετικέτες
Πληροφορίες
Τετάρτη 6 Σεπτεμβρίου 2017
The Contribution of Singlet Oxygen to Insulin Resistance
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αναζήτηση αυτού του ιστολογίου
! # Ola via Alexandros G.Sfakianakis on Inoreader
-
Publication date: 1 May 2019 Source: Talanta, Volume 196 Author(s): Ruiqing Long, Te Li, Chaoying Tong, Lihui Wu, Shuyun Shi Abstract...
-
Oral Cancer Rapid Test Kit Market Rugged Expansion Foreseen by 2024 MilTech Oral cancer is one of the largest group of cancers ...
-
Related Articles SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,