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Τετάρτη 6 Σεπτεμβρίου 2017

Siglec-8 is an activating receptor mediating β2 integrin-dependent function in human eosinophils

Siglec-8 can unexpectedly function as an activating receptor, not an inhibitory receptor, because its engagement on IL-5-primed eosinophils promotes β2-integrin-mediated adhesion and activates NADPH oxidase and protein kinases, all of which are necessary for causing human eosinophil apoptosis.

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,

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