Nephroprotective effect of Murraya koenigii on cyclophosphamide induced nephrotoxicity in rats

Publication date: Available online 24 August 2017
Source:Asian Pacific Journal of Tropical Medicine
Author(s): Patel Mahipal, Rajesh Singh Pawar
ObjectiveTo evaluate the nephroprotective effect of defatted mehtanolic extract and aqueous extract of Murraya koenigii against cyclophosphamide drug.MethodsNephrotoxicity was induced by cyclophosphamide in 7 days at 150 mg/kg body weight through intraperitoneal route in rat model. Nephroprotective activity of Murraya koenigii extract (100 mg/kg and 200 mg/kg in intraperitoneal route) was measured, including nephrological source, oxidative stress parameters like superoxide dismutase, glutathione, the lipid peroxide and in vivo assay like blood urea nitrogen, creatinine were determined and analyzed by One way analysis of variance followed by Tukey's test.ResultsThe study result showed that important phytochemicals such as carbohydrates, flavonoids, tannin, alkaloids, glycosides, protein and steroids were found to be present in the extract of Murraya koenigii. The renal function markers like blood urea nitrogen and ceatinine level were found to be decreased significantly by M. koenigii extract treatment. A significant difference was found to be at P<0.01.ConclusionsThe present study reveals the protective role of Murraya koenigii extract against cyclophosphamide induced nephrotoxicity.

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