Introduction to the Thematic Minireview Series: Redox Metabolism and Signaling [Metabolism]

Life on oxygen predisposes cells to reactive oxygen species (ROS) generation by electron slippage in the electron transfer chain. Aerobic metabolism also generates as bonafide products, superoxide (O2-) and hydrogen peroxide (H2O2), in reactions involving one- or two-electron reduction of O2. Though often viewed as dangerous, ROS are now recognized as important messengers in redox signaling pathways. A delicate balance between needed versus excessive ROS production distinguishes health from an array of disease states. A collection of provocative reviews in this thematic series, discusses the relative importance of mitochondrial sites for ROS production, ROS signaling-mediated regulation of cellular stress responses and thermogenesis, and how O2 deficiency leads to metabolic reprograming in cancer.

from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2wL7SgI
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