Antibodies, Vol. 6, Pages 11: Monoclonal Antibodies against Plasmodium falciparum Circumsporozoite Protein

Antibodies, Vol. 6, Pages 11: Monoclonal Antibodies against Plasmodium falciparum Circumsporozoite Protein

Antibodies doi: 10.3390/antib6030011

Authors: Min Zhang Rajakumar Mandraju Urvashi Rai Takayuki Shiratsuchi Moriya Tsuji

Malaria is a mosquito-borne infectious disease caused by the parasite Plasmodium spp. Malaria continues to have a devastating impact on human health. Sporozoites are the infective forms of the parasite inside mosquito salivary glands. Circumsporozoite protein (CSP) is a major and immunodominant protective antigen on the surface of Plasmodium sporozoites. Here, we report a generation of specific monoclonal antibodies that recognize the central repeat and C-terminal regions of P. falciparum CSP. The monoclonal antibodies 3C1, 3C2, and 3D3—specific for the central repeat region—have higher titers and protective efficacies against challenge with sporozoites compared with 2A10, a gold standard monoclonal antibody that was generated in early 1980s.

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