Immune checkpoint blockade for unresectable or metastatic uveal melanoma: a systematic review

Uveal melanoma (UM) is an ocular malignancy which originates from melanocytes residing in the choroid layer of the eye. With an incidence of 4-7 cases per million in Europe, it is much rarer than cutaneous melanoma [1]. Several risk factors for the development of UM have been identified in observational studies, including the presence of choroidal or cutaneous nevi, fair skin, light eye color, and exposure to ultraviolet radiation [2].

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