Light controlled metallo-drug delivery system based on the TiO2-nanoparticles and Ru-complex

Publication date: 1 October 2017 Source:Journal of Photochemistry and Photobiology A: Chemistry, Volume 347 Author(s): Maja Nešić, Jelena Žakula, Lela Korićanac, Milutin Stepić, Marija Radoičić, Iva Popović, Zoran Šaponjić, Marijana Petković We studied the colloidal TiO2 nanoparticles as a carrier for controlled delivery of the ruthenium complex to the melanoma cell line. The system demonstrated slower complex release upon visible and increased release rate upon UV light illumination. Accordingly, the light–dependent cytotoxicity of the system was demonstrated on amelanotic melanoma cancer line. The cell death is enhanced by UV and reduced by red light in the presence of investigated nanocomposite system. Both components of the system may act as photosensitizers, by generatin...

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