Temporal Changes in Later Cancers Among Childhood Cancer Survivors —Reply

In Reply Dr Tanimoto and colleagues query whether treatment with HCT was considered in our analysis of temporal changes in subsequent neoplasms in the Childhood Cancer Survivor Study (CCSS). They raise the point that treatment modalities used in the context of HCT, such as the dose and intensity of chemotherapy, total body irradiation, or both, are unique and also point out the potential importance of chronic GVHD as a risk factor for subsequent neoplasms. (Source: JAMA)

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