Hypoxia inducible factor-1 α regulates autophagy via the p27-E2F1 signaling pathway.

Hypoxia inducible factor-1α regulates autophagy via the p27-E2F1 signaling pathway. Mol Med Rep. 2017 Jun 15;: Authors: Wang P, Long M, Zhang S, Cheng Z, Zhao X, He F, Liu H, Ming L Abstract Autophagy is a highly conserved process by which the cell contents are delivered to lysosomes for degradation, or are used to provide macromolecules for energy generation under conditions of nutritional starvation. It has previously been demonstrated that cancer cells in hypoxic regions, with an oxygen concentration below the normal physiological level, express hypoxia inducible factor (HIF)‑1α, in order to adapt and survive. HIF‑1α is important in the regulation of oxygen homeostasis and the transcription of hundreds of genes in response to conditions of hypoxia, hence main...

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