Different patterns of expression of cell cycle control and local invasion-related proteins in oral squamous cell carcinoma affecting young patients.

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Different patterns of expression of cell cycle control and local invasion-related proteins in oral squamous cell carcinoma affecting young patients.

J Oral Pathol Med. 2017 Jun 19;:

Authors: Miranda Galvis M, Santos-Silva AR, Jardim JF, Fonseca FP, Lopes MA, Almeida OP, Lópes Pinto CA, Kaminagakura E, Sawazaki-Calone I, Speight PM, Kowalski LP

Abstract
Oral squamous cell carcinoma (OSCC) predominantly affects males in the fifth decade of life; nevertheless, an increased incidence in young patients has been reported worldwide and the clinical and behavioral characteristics of tumors in this group are controversial and the literature shows divergent results PURPOSE: To investigate the clinicopathological features and prognostic significance of the immunoexpression of cell cycle and local invasion proteins in OSCC affecting young patients (≤ 40 years old) METHODS: A tissue microarray was performed with 132 OSCC samples (61 cases of young patients vs. 71 cases of elderly patients) and submitted to immunohistochemical reactions with Ki67, p53, p16, Bcl-2, Cyclin D1, C-ErbB2, p21, Myc, EGFR, MMP-9, SMA, Cathepsin K and FGF-2 antibodies RESULTS: Clinicopathological features and survival rates were similar in both groups. Although overexpression of EGFR (p = 0.042) and MMP-9 (p = 0.001) was more frequent in young patients, only C-ErbB-2 (p = 0.048) and SMA (p = 0.048) expression correlated with lower DFS in this group of patients CONCLUSION: Clinicopathological features and survival rates are similar between younger and older patients with OSCC. The different patterns of C-ErbB2, EGFR, MMP-9 and SMA expression between the groups merits further investigation to understand their role in the early tumor onset in young patients. This article is protected by copyright. All rights reserved.

PMID: 28626969 [PubMed - as supplied by publisher]

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