Role of liver-X-receptors in airway remodeling in mice with chronic allergic asthma

xlomafota13 shared this article with you from Inoreader Role of liver-X-receptors in airway remodeling in mice with chronic allergic asthma Via Experimental and therapeutic medicine Exp Ther Med. 2021 Sep;22(3):920. doi: 10.3892/etm.2021.10352. Epub 2021 Jun 30. ABSTRACT Liver X receptors (LXRs) exert anti-inflammatory effects in animal models of certain respiratory diseases. In the present study, a model of chronic airway remodeling was established in wild-type and LXR-deficient mice. Ovalbumin (OVA)-sensitized mice were chronically administered OVA via inhalation for 8 weeks. Prior to each stimulation, certain wild-type mice were treated with GW3965, which is a highly selective LXR agonist. The influence of LXRs on airway inflammation, airway hyperresponsiveness and airway remodeling was evaluated. LXRs were indicated to increase airway inflammation and airway hyperresponsiveness, as well as promote airway remodeling. These results suggest that inhibiting LXRs may be a potential method for the treatment of allergic asthma. PMID:34335881 | PMC:PMC8290420 | DOI:10.3892/etm.2021.10352 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.