Applicability and implementation of the collagen-induced arthritis mouse model, including protocols (Review)

xlomafota13 shared this article with you from Inoreader Applicability and implementation of the collagen-induced arthritis mouse model, including protocols (Review) Via Experimental and therapeutic medicine Exp Ther Med. 2021 Sep;22(3):939. doi: 10.3892/etm.2021.10371. Epub 2021 Jul 1. ABSTRACT Animal models of rheumatoid arthritis (RA) are essential for studying the pathogenesis of RA in vivo and determining the efficacy of anti-RA drugs. During the past decades, numerous rodent models of arthritis have been evaluated as potential models and the modeling methods are relatively well-developed. Among these models, the collagen-induced arthritis (CIA) mouse model is the first choice and the most widely used because it may be generated rapidly and inexpensively and is relatively similar in pathogenesis to human RA. To date, there have been numerous classic studies and reviews discussing related pathogeneses and modeling methods. Based on this knowledge, combined with the latest convenient and effective methods for CIA model construction, the present review aims to introduce the model to beginners and clarify important details regardin g its use. Information on the origin and pathogenesis of the CIA model, the protocol for establishing it, the rate of successful arthritis induction and the methods used to evaluate the severity of arthritis are briefly summarized. With this information, it is expected that researchers who have recently entered the field or are not familiar with this information will be able to start quickly, avoid unnecessary errors and obtain reliable results. PMID:34335888 | PMC:PMC8290431 | DOI:10.3892/etm.2021.10371 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.