Methylation patterns of cutaneous T‐cell lymphomas

xlomafota13 shared this article with you from Inoreader Methylation patterns of cutaneous T‐cell lymphomas Via Experimental Dermatology Abstract In cutaneous T-cell lymphoma (CTCL), global hypomethylation of the genome and hypermethylation of tumor suppressor genes were detected. Studies show that methylation dysregulation is often a starting point for processes that might lead to malignant transformation. In this review, all data regarding copy-number variations (CNVs) and mutations in main methylation players DNA methyltransferases/TET in CTCL were summarized. An overview of studies on gene-specific hypomethylation and hypermethylation in CTCL, including methylation of microRNA genes, was presented. The possibility of using the methylation pattern in diagnosis and methylation inhibitors in treatment of CTCL was discussed. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.