Effects of Ibrutinib on biophysical parameters of platelet in patients with chronic lymphocytic leukaemia

xlomafota13 shared this article with you from Inoreader Effects of Ibrutinib on biophysical parameters of platelet in patients with chronic lymphocytic leukaemia Via American Journal of Blood Research Am J Blood Res. 2020 Dec 15;10(6):311-319. eCollection 2020. ABSTRACT Patients with chronic lymphocytic leukemia (CLL) treated with Ibrutinib often present hemorrhagic complications. Platelets dysfunction is well documented by aggregometry and flow cytometry, but the mechanisms by which Ibrutinib treatment influences the platelets status is yet to be evaluated. The aim of this study is to identify platelet membrane parameters in chronic lymphocytic leukemia (CLL) that could be altered by Ibrutinib administration. In this paper we propose a set of fluorescence measurements of the following parameters: membrane fluidity, resting membrane potential, and reactive oxygen species production of platelets suspensions obtained from CLL patients treated or not with Ibrutinib as markers for platelets status in this pathological situation. Platelets from CLL patients treated with Ibrutinib have higher membrane fluidity, lower resting membrane pote ntial and higher level of reactive oxygen species production compared to the untreated CLL patients. These patients are also presenting higher membrane fluidity and lower resting membrane potential compared to healthy volunteers. PMID:33489439 | PMC:PMC7811905 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.