Childhood psoriasis: Disease spectrum, comorbidities, and challengesSoumajyoti Sarkar, Sandipan Dhar, Siba P RaychaudhuriIndian Journal of Paediatric Dermatology 2019 20(3):191-198Psoriasis is a chronic, inflammatory, papulosquamous disorder with a variable clinical spectrum. Although it affects population of all age groups, the significance and negative impact of childhood psoriasis is often neglected worldwide. In nearly one-third of the psoriatic population, psoriasis appears during the childhood....
Current market trends in anterior ocular inflammatory disease landscapePurpose of review In the US anterior ocular inflammatory disease (AOID) composed of the spectrum of ocular allergies, different forms of infectious conjunctivitis, and dry eye diseases, affects over 40% of the population. This review evaluates the current economic costs for AOID associated pharmacotherapies. Recent findings In recent years, with improved understanding in pathophysiology of the AOID, providing novel targets for...
Buddhists Care: Examining the Impact of Religious Elements on Reducing Discriminatory Attitudes toward People Living with HIV/AIDS03:00by Song via ReligionsReligions, Vol. 10, Pages 409: Buddhists Care: Examining the Impact of Religious Elements on Reducing Discriminatory Attitudes toward People Living with HIV/AIDSReligions doi: 10.3390/rel10070409Authors: Song QinFaith-based programs have been long regarded as influential social approaches to form positive attitudes to human immunodeficiency virus...
Invasive and Non-Invasive Fungal Rhinosinusitis—A Review and Update of the Evidence03:00by Deutsch via MedicinaMedicina, Vol. 55, Pages 319: Invasive and Non-Invasive Fungal Rhinosinusitis—A Review and Update of the EvidenceMedicina doi: 10.3390/medicina55070319Authors: Deutsch Whittaker PrasadFungal infections are a subset of infectious processes that an otolaryngologist is required to be familiar with. They can be encountered in otology, rhinology and head and neck surgery. The presence of fungal...
IJMS, Vol. 20, Pages 3182: Renin Activity in Heart Failure with Reduced Systolic Function—New InsightsIJMS, Vol. 20, Pages 3182: Renin Activity in Heart Failure with Reduced Systolic Function—New Insights International Journal of Molecular Sciences doi: 10.3390/ijms20133182 Authors: Ryan D. Sullivan Radhika M. Mehta Ranjana Tripathi Guy L. Reed Inna P. Gladysheva Regardless of the cause, symptomatic heart failure (HF) with reduced ejection fraction (rEF) is characterized by pathological activation...
IJERPH, Vol. 16, Pages 2300: Multi-Indicator Approach for Characterising Urban Green Space Provision at City and City-District Level in GermanyIJERPH, Vol. 16, Pages 2300: Multi-Indicator Approach for Characterising Urban Green Space Provision at City and City-District Level in Germany International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16132300 Authors: Grunewald Richter Behnisch This paper addresses the question of how a sustainable urban development can be supported...
Humanities, Vol. 8, Pages 118: A Mind Trying to Right/Write Itself: Metaphors in Madness NarrativesHumanities, Vol. 8, Pages 118: A Mind Trying to Right/Write Itself: Metaphors in Madness Narratives Humanities doi: 10.3390/h8020118 Authors: Renana Stanger Elran This article explores autobiographical madness narratives written by people with lived experience of psychosis, dated from the mid-19th century until the 1970s. The focus of the exploration is on the metaphors used in these narratives in order...
Heritage, Vol. 2, Pages 1748-1761: Contemporary Landscape Structure within Monumental Zone-1 at Bagan Cultural Heritage Site, MyanmarHeritage, Vol. 2, Pages 1748-1761: Contemporary Landscape Structure within Monumental Zone-1 at Bagan Cultural Heritage Site, Myanmar Heritage doi: 10.3390/heritage2020107 Authors: Min Zar Ni Aung Shozo Shibata This study examines the contemporary landscape structure of the Monumental Zone (MZ)-1 at the Bagan Cultural Heritage Site in the Dry Zone of Myanmar. With respect...
Healthcare, Vol. 7, Pages 82: The Power of Music: Enhancing Muscle Strength in Older PeopleHealthcare, Vol. 7, Pages 82: The Power of Music: Enhancing Muscle Strength in Older People Healthcare doi: 10.3390/healthcare7030082 Authors: Nadja van den Elzen Vera Daman Merel Duijkers Kim Otte Esmée Wijnhoven Hans Timmerman Marcel Olde Rikkert Sarcopenia is a major problem occurring in the aging population. Based on previous research, music appears to have a positive influence on many aspects of life,...
Geriatrics, Vol. 4, Pages 40: Geriatric Assessment in Multicultural Immigrant PopulationsGeriatrics, Vol. 4, Pages 40: Geriatric Assessment in Multicultural Immigrant Populations Geriatrics doi: 10.3390/geriatrics4030040 Authors: Katherine T. Ward Mailee Hess Shirley Wu While the traditional comprehensive geriatric assessment provides valuable information essential to caring for older adults, it often falls short in multicultural immigrant populations. The number of foreign-born older adults is growing,...
GastrointestDisord, Vol. 1, Pages 290-300: Immunomodulatory Effects of TGF-β Family Signaling within Intestinal Epithelial Cells and CarcinomasGastrointestDisord, Vol. 1, Pages 290-300: Immunomodulatory Effects of TGF-β Family Signaling within Intestinal Epithelial Cells and Carcinomas Gastrointestinal Disorders doi: 10.3390/gidisord1020024 Authors: Paula Marincola Smith Anna Means R. Beauchamp TGF-β superfamily signaling is responsible for many critical cellular functions including control of cell...
Fractal Fract, Vol. 3, Pages 37: Inequalities Pertaining Fractional Approach through Exponentially Convex FunctionsFractal Fract, Vol. 3, Pages 37: Inequalities Pertaining Fractional Approach through Exponentially Convex Functions Fractal and Fractional doi: 10.3390/fractalfract3030037 Authors: Saima Rashid Muhammad Aslam Noor Khalida Inayat Noor In this article, certain Hermite-Hadamard-type inequalities are proven for an exponentially-convex function via Riemann-Liouville fractional integrals that...
Foods, Vol. 8, Pages 231: Use of Attenuated Total Reflectance—Fourier Transform Infrared (ATR-FTIR) Spectroscopy in Combination with Multivariate Methods for the Rapid Determination of the Adulteration of Grape, Carob and Mulberry PekmezFoods, Vol. 8, Pages 231: Use of Attenuated Total Reflectance—Fourier Transform Infrared (ATR-FTIR) Spectroscopy in Combination with Multivariate Methods for the Rapid Determination of the Adulteration of Grape, Carob and Mulberry Pekmez Foods doi: 10.3390/foods8070231...
Fermentation, Vol. 5, Pages 52: Solid State Fermentation of Brewers' Spent Grains for Improved Nutritional Profile Using Bacillus subtilis WX-17Fermentation, Vol. 5, Pages 52: Solid State Fermentation of Brewers' Spent Grains for Improved Nutritional Profile Using Bacillus subtilis WX-17 Fermentation doi: 10.3390/fermentation5030052 Authors: Yong Xing Tan Wai Kit Mok Jaslyn Lee Jaejung Kim Wei Ning Chen Brewers' spent grains (BSG) are underutilized food waste materials produced in large quantities...
EJIHPE, Vol. 10, Pages 1-9: Intergroup Discrimination as a Predictor of Conflict within the Same Organization. The Role of Organizational IdentityEJIHPE, Vol. 10, Pages 1-9: Intergroup Discrimination as a Predictor of Conflict within the Same Organization. The Role of Organizational Identity European Journal of Investigation in Health, Psychology and Education doi: 10.3390/ejihpe10010001 Authors: Samuel Fernández-Salinero Gabriela Topa The main purpose of this research is to shed light upon how perception...
Epigenomes, Vol. 3, Pages 12: Polycomb Assemblies Multitask to Regulate Transcription Epigenomes,...
Epigenomes, Vol. 3, Pages 12: Polycomb Assemblies Multitask to Regulate TranscriptionEpigenomes, Vol. 3, Pages 12: Polycomb Assemblies Multitask to Regulate Transcription Epigenomes doi: 10.3390/epigenomes3020012 Authors: Miguel Vidal The Polycomb system is made of an evolutionary ancient group of proteins, present throughout plants and animals. Known initially from developmental studies with the fly Drosophila melanogaster, they were associated with stable sustainment of gene repression and maintenance...
Environments, Vol. 6, Pages 75: Current Status of Las Tablas de Daimiel National Park Wetland and...
Environments, Vol. 6, Pages 75: Current Status of Las Tablas de Daimiel National Park Wetland and Actions Required for ConservationEnvironments, Vol. 6, Pages 75: Current Status of Las Tablas de Daimiel National Park Wetland and Actions Required for Conservation Environments doi: 10.3390/environments6060075 Authors: Sandra Bravo-Martin Miguel Mejías Francisco J. García-Navarro Raimundo Jiménez-Ballesta Wetlands are complex ecosystems that play multiple roles. 'Las Tablas de Daimiel National Park'...
Diversity, Vol. 11, Pages 102: New Material of Paleocene-Eocene Pellornis (Aves: Gruiformes) Clarifies the Pattern and Timing of the Extant Gruiform RadiationDiversity, Vol. 11, Pages 102: New Material of Paleocene-Eocene Pellornis (Aves: Gruiformes) Clarifies the Pattern and Timing of the Extant Gruiform Radiation Diversity doi: 10.3390/d11070102 Authors: Grace Musser Daniel T. Ksepka Daniel J. Field Pellornis mikkelseni is an early gruiform from the latest Paleocene-earliest Eocene Fur Formation...
Diseases, Vol. 7, Pages 47: Cell and Gene Therapies for Mucopolysaccharidoses: Base Editing and Therapeutic Delivery to the CNSAlthough individually uncommon, rare diseases collectively account for a considerable proportion of disease impact worldwide. A group of rare genetic diseases called the mucopolysaccharidoses (MPSs) are characterized by accumulation of partially degraded glycosaminoglycans cellularly. MPS results in varied systemic symptoms and in some forms of the disease, neurodegeneration....
Diagnostics, Vol. 9, Pages 66: In vivo Diagnosis of Primary Cutaneous Amyloidosis —the Role of Reflectance Confocal MicroscopyPrimary cutaneous amyloidosis (PCA) is a form of localized amyloidosis. It is characterized by the deposition of a fibrillar material in the superficial dermis, without affecting other systems or organs. The diagnosis can be made clinically, but usually a skin biopsy is performed in order to exclude other skin diseases with similar appearance. Reflectance confocal microscopy...
Dentistry Journal, Vol. 7, Pages 64: Impact of Different Irrigant Agitation Methods on Bacterial Elimination from Infected Root CanalsActivation techniques are essential for root canal disinfection but may result in incomplete removal of bacteria. The aim of our study was to assess the antibacterial action of sonically, ultrasonically and laser-activated irrigation and 5.25% sodium hypochlorite (NaOCl) on Enterococcus faecalis in an infected tooth. Forty-four extracted mandibular premolars were mechanically...
Cryptography, Vol. 3, Pages 16: I2PA: An Efficient ABC for IoTThe Internet of Things (IoT) is very attractive because of its promises. However, it brings many challenges, mainly issues about privacy preservation and lightweight cryptography. Many schemes have been designed so far but none of them simultaneously takes into account these aspects. In this paper, we propose an efficient attribute-based credential scheme for IoT devices. We use elliptic curve cryptography without pairing, blind signing,...
Cosmetics, Vol. 6, Pages 36: Unique Hair Properties that Emerge from Combinations of Multiple RacesThe fusion of ethnicity in human populations is becoming increasingly common, so the conventional definition of ethnicity is going to become deficient. The aim of this study was to investigate the hair properties which emerge from combinations of multiple races. Hair fibers collected from mixed-race subjects were investigated and classifications of hair shape as well as measurements of thickness, ellipticity...
Clocks & Sleep, Vol. 1, Pages 280-289: How to Report Light Exposure in Human Chronobiology and Sleep Research ExperimentsExposure to light has short- and long-term impacts on non-visual responses in humans. While many aspects related to non-visual light sensitivity have been characterised (such as the action spectrum for melatonin suppression), much remains to be elucidated. Here, we provide a set of minimum reporting guidelines for reporting the stimulus conditions involving light as an intervention...
Climate, Vol. 7, Pages 84: The Effect of Agulhas Eddies on Absorption and Transport of Anthropogenic Carbon in the South Atlantic OceanThe South Atlantic Ocean is currently undergoing significant alterations due to climate change. This region is important to the global carbon cycle, but marine carbon data are scarce in this basin. Additionally, this region is influenced by Agulhas eddies. However, their effects on ocean biogeochemistry are not yet fully understood. Thus, we aimed to model the carbonate...
Clean Technol., Vol. 1, Pages 141-153: Optimization of Alachlor Photocatalytic Degradation with Nano-TiO2 in Water under Solar Illumination: Reaction Pathway and MineralizationIn the present study, the photocatalytic degradation of alachlor was investigated using TiO2 under sunlight irradiation. The effects of some operational parameters, such as photocatalyst concentration, temperature, pH, sunlight intensity and irradiation time, were optimized. The kinetics of photodegradation was found to follow...
Children, Vol. 6, Pages 81: Effects of Gestational Age and Early Parenting on Children's Social Inhibition at 6 YearsPreterm birth (<37 weeks' gestation) has been associated with problems in social functioning. Whether social inhibition is specifically related to preterm birth and whether early parenting may protect against social inhibition difficulties is unknown. To explore effects of gestational age and early parent–infant relationships on social inhibition, 1314 children born at 26–41 weeks...
Cells, Vol. 8, Pages 649: Nuclear Phosphoinositides—Versatile Regulators of Genome FunctionsThe many functions of phosphoinositides in cytosolic signaling were extensively studied; however, their activities in the cell nucleus are much less clear. In this review, we summarize data about their nuclear localization and metabolism, and review the available literature on their involvements in chromatin remodeling, gene transcription, and RNA processing. We discuss the molecular mechanisms via which nuclear...
Cancers, Vol. 11, Pages 911: Decoding Immune Heterogeneity of Triple Negative Breast Cancer and Its Association with Systemic InflammationTriple negative breast cancer (TNBC) is an aggressive subtype with limited therapeutic options. New opportunities are emerging from current comprehensive characterization of tumor immune infiltration and fitness. Therefore, effectiveness of current chemotherapies and novel immunotherapies are partially dictated by host inflammatory and immune profiles. However,...
C, Vol. 5, Pages 35: A Simple Two-Step Process for Producing Strong and Aligned Carbon Nanotube-Polymer CompositesIn this paper, we present the results of a study related to fabrication of polymer-aligned carbon nanotube (CNT) composites made with different thermoplastic polymers. These composites have been manufactured by employing a simple two-step process using the internal resistive heating approach. The resulting composites have shown improved tensile strength, load, and elastic modulus compared...
Brain Sciences, Vol. 9, Pages 154: Neural Sensitivity to Mutual Information in Intermediate-Complexity Face Features Changes during ChildhoodOne way in which face recognition develops during infancy and childhood is with regard to the visual information that contributes most to recognition judgments. Adult face recognition depends on critical features spanning a hierarchy of complexity, including low-level, intermediate, and high-level visual information. To date, the development of adult-like information...
Biomolecules, Vol. 9, Pages 255: Site-Specific Incorporation of Unnatural Amino Acids into Escherichia coli Recombinant Protein: Methodology Development and Recent AchievementMore than two decades ago a general method to genetically encode noncanonical or unnatural amino acids (NAAs) with diverse physical, chemical, or biological properties in bacteria, yeast, animals and mammalian cells was developed. More than 200 NAAs have been incorporated into recombinant proteins by means of non-endogenous...
Biomolecules, Vol. 9, Pages 255: Site-Specific Incorporation of Unnatural Amino Acids into Escherichia coli Recombinant Protein: Methodology Development and Recent AchievementMore than two decades ago a general method to genetically encode noncanonical or unnatural amino acids (NAAs) with diverse physical, chemical, or biological properties in bacteria, yeast, animals and mammalian cells was developed. More than 200 NAAs have been incorporated into recombinant proteins by means of non-endogenous...
Biomimetics, Vol. 4, Pages 43: Matrix Nanopatterning Regulates Mesenchymal Differentiation through Focal Adhesion Size and Distribution According to Cell FateExtracellular matrix remodeling plays a pivotal role during mesenchyme patterning into different lineages. Tension exerted from cell membrane receptors bound to extracellular matrix ligands is transmitted by the cytoskeleton to the cell nucleus inducing gene expression. Here, we used dendrimer-based arginine–glycine–aspartic acid (RGD) uneven...
Biomedicines, Vol. 7, Pages 46: Protein Nanotubes: From Bionanotech towards Medical ApplicationsNanobiotechnology involves the study of structures found in nature to construct nanodevices for biological and medical applications with the ultimate goal of commercialization. Within a cell most biochemical processes are driven by proteins and associated macromolecular complexes. Evolution has optimized these protein-based nanosystems within living organisms over millions of years. Among these are flagellin...
Biology, Vol. 8, Pages 52: The Use of Myelinating Cultures as a Screen of Glycomolecules for CNS RepairIn vitro cell-based assays have been fundamental in modern drug discovery and have led to the identification of novel therapeutics. We have developed complex mixed central nervous system (CNS) cultures, which recapitulate the normal process of myelination over time and allow the study of several parameters associated with CNS damage, both during development and after injury or disease. In particular,...
Bioengineering, Vol. 6, Pages 55: Influence of Pathogens and Mechanical Stimuli in InflammationInflammation is a process driven by underlying cell-cell communication and many other factors. In this study, a model of cell-cell communications was proposed to study factors driving the inflammation time course. Analyses of inflammations that are driven by the combined effects of strain (mechanical stimuli) and/or pathogens are considered in this paper. An agent-based model was employed to simulate inflammation...
Beverages, Vol. 5, Pages 40: Biogenic Amines Determination in "Plant Milks""Plant milks" are water-based beverages, such as, extracts from cereals, pseudo-cereals, oil seeds, legumes or fruits. Plant milk consumption is rising in European and North American markets due to problems related to cow milk allergies, intolerances, but also because of vegan diets and sensitivity to environmental issues. There is no specific regulation for these beverages, therefore their composition can vary considerably,...
Behavioral Sciences, Vol. 9, Pages 69: The Push and Pull of Network Mobility: How Those High in Trait-Level Neuroticism Can Come to Occupy Peripheral Network PositionsField research shows that people's network positions are determined, at least in part, by their traits. For instance, over time, actors higher in trait-level neuroticism move out to the network periphery. What is unknown is how this happens. Drawing on personality and social psychological theory, we generated a model that could explain...
Atmosphere, Vol. 10, Pages 358: Dust-Associated Airborne Microbes Affect Primary and Bacterial Production Rates, and Eukaryotes Diversity, in the Northern Red Sea: A Mesocosm ApproachThe northern Red Sea (NRS) is a low-nutrient, low-chlorophyll (LNLC) ecosystem with high rates of atmospheric deposition due to its proximity to arid regions. Impacts of atmospheric deposition on LNLC ecosystems have been attributed to the chemical constituents of dust, while overlooking bioaerosols. Understanding how...
Beverages, Vol. 5, Pages 40: Biogenic Amines Determination in "Plant Milks""Plant milks" are water-based beverages, such as, extracts from cereals, pseudo-cereals, oil seeds, legumes or fruits. Plant milk consumption is rising in European and North American markets due to problems related to cow milk allergies, intolerances, but also because of vegan diets and sensitivity to environmental issues. There is no specific regulation for these beverages, therefore their composition can vary considerably,...
Behavioral Sciences, Vol. 9, Pages 69: The Push and Pull of Network Mobility: How Those High in Trait-Level Neuroticism Can Come to Occupy Peripheral Network PositionsField research shows that people's network positions are determined, at least in part, by their traits. For instance, over time, actors higher in trait-level neuroticism move out to the network periphery. What is unknown is how this happens. Drawing on personality and social psychological theory, we generated a model that could explain...
Atmosphere, Vol. 10, Pages 358: Dust-Associated Airborne Microbes Affect Primary and Bacterial Production Rates, and Eukaryotes Diversity, in the Northern Red Sea: A Mesocosm ApproachThe northern Red Sea (NRS) is a low-nutrient, low-chlorophyll (LNLC) ecosystem with high rates of atmospheric deposition due to its proximity to arid regions. Impacts of atmospheric deposition on LNLC ecosystems have been attributed to the chemical constituents of dust, while overlooking bioaerosols. Understanding how...
Arts, Vol. 8, Pages 77: The Painting Industries of Antwerp and Amsterdam, 1500−1700: A Data PerspectiveThis study presents a data driven comparative analysis of the painting industries in sixteenth and seventeenth century Antwerp and Amsterdam. The popular view of the development of these two artistic centers still holds that Antwerp flourished in the sixteenth century and was succeeded by Amsterdam after the former's recapturing by the Spanish in 1585. However, a demographic analysis of the number...
Antioxidants, Vol. 8, Pages 200: Optimization of Ultrasound-Assisted Extraction of Antioxidant Polyphenols from the Seed Coats of Red Sword Bean (Canavalia gladiate (Jacq.) DC.)The seed coat of red sword bean (Canavalia gladiata (Jacq.) DC.) is rich in antioxidant polyphenols. It is often discarded as a byproduct with the consumption of red sword bean, since it is very thick and not consumed by people. The aim of this study was to develop an ultrasound-assisted extraction method to extract natural...
Antibodies, Vol. 8, Pages 38: Super Potent Bispecific Llama VHH Antibodies Neutralize HIV via a Combination of gp41 and gp120 EpitopesBroad and potent neutralizing llama single domain antibodies (VHH) against HIV-1 targeting the CD4 binding site (CD4bs) have previously been isolated upon llama immunization. Here we describe the epitopes of three additional VHH groups selected from phage libraries. The 2E7 group binds to a new linear epitope in the first heptad repeat of gp41 that is only exposed...
Antibiotics, Vol. 8, Pages 85: Antimicrobial Resistance in Bacterial Pathogens and Detection of Carbapenemases in Klebsiella pneumoniae Isolates from Hospital WastewaterDuring a six-month period (October 2017–March 2018), the prevalence and susceptibility of important pathogenic bacteria isolated from 12 hospital raw sewage samples in North Western Greece was investigated. The samples were analyzed for methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), extended-spectrum...
Acoustics, Vol. 1, Pages 450-472: Wave Mode Identification of Acoustic Emission Signals Using Phase AnalysisAcoustic Emission (AE) monitoring can be used to detect and locate structural damage such as growing fatigue cracks. The accuracy of damage location and consequently the inference of its significance for damage assessment is dependent on the wave propagation properties in terms of wave velocity, dispersion, attenuation and wave mode conversion. These behaviors are understood and accounted for...
Nutrients, Vol. 11, Pages 1477: Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over StudyOral diabetes-specific nutritional supplements (ONS-D) induce favourable postprandial responses in subjects with type 2 diabetes (DM2), but they have not been correlated yet with incretin release and subjective appetite (SA). This randomised,...
Genes, Vol. 10, Pages 492: Cloudy with a Chance of Insights: Context Dependent Gene Regulation and Implications for Evolutionary StudiesResearch in various fields of evolutionary biology has shown that divergence in gene expression is a key driver for phenotypic evolution. An exceptional contribution of cis-regulatory divergence has been found to contribute to morphological diversification. In the light of these findings, the analysis of genome-wide expression data has become one of the central tools...
Pansacramentalism, Interreligious Theology, and Lived Religion03:00by Hans Gustafson via MDPI PublishingReligions, Vol. 10, Pages 408: Pansacramentalism, Interreligious Theology, and Lived ReligionReligions doi: 10.3390/rel10070408Authors: Hans GustafsonOpening with a philosophical definition of sacrament(ality) as a mediator (mediation) of the sacred in the concrete world, this article offers pansacramentalism as a promising worldview—especially for those rooted in or emerging from the Christian...
Cancers, Vol. 11, Pages 911: Decoding Immune Heterogeneity of Triple Negative Breast Cancer and Its Association with Systemic InflammationTriple negative breast cancer (TNBC) is an aggressive subtype with limited therapeutic options. New opportunities are emerging from current comprehensive characterization of tumor immune infiltration and fitness. Therefore, effectiveness of current chemotherapies and novel immunotherapies are partially dictated by host inflammatory and immune profiles. However,...
Ovarian Cancer Stemness: Biological and Clinical Implications for Metastasis and Chemotherapy Resistance03:00by Takeshi Motohara via MDPI PublishingCancers, Vol. 11, Pages 907: Ovarian Cancer Stemness: Biological and Clinical Implications for Metastasis and Chemotherapy ResistanceCancers doi: 10.3390/cancers11070907Authors: Takeshi Motohara Hidetaka KatabuchiEpithelial ovarian cancer is a highly lethal gynecological malignancy that is characterized by the early development of disseminated metastasis....
International Journal of Molecular Sciences,IJMS, Vol. 20, Pages 3175: Sex- and Age-Related Estrogen Signaling Alteration in Inflammatory Bowel Diseases: Modulatory Role of Estrogen ReceptorsIJMS, Vol. 20, Pages 3175: Sex- and Age-Related Estrogen Signaling Alteration in Inflammatory Bowel Diseases: Modulatory Role of Estrogen Receptors International Journal of Molecular Sciences doi: 10.3390/ijms20133175 Authors: Damian Jacenik Adam I. Cygankiewicz Anna Mokrowiecka Ewa Małecka-Panas Jakub Fichna...
Clinical Trials News,Janssen Receives Positive CHMP Opinion Recommending Expanded Use of Imbruvica®▼(ibrutinib) in Two Indications in EuropeBEERSE, Belgium--(BUSINESS WIRE)--The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has recommended broadening the existing marketing authorisation for Imbruvica® (ibrutinib) in two indications. One recommendation is for the use of...
Wnt-11 as a Potential Prognostic Biomarker and Therapeutic Target in Colorectal Cancer03:00by Irantzu Gorroño-Etxebarria via MDPI PublishingCancers, Vol. 11, Pages 908: Wnt-11 as a Potential Prognostic Biomarker and Therapeutic Target in Colorectal CancerCancers doi: 10.3390/cancers11070908Authors: Irantzu Gorroño-Etxebarria Urko Aguirre Saray Sanchez Nerea González Antonio Escobar Ignacio Zabalza José Maria Quintana Maria dM Vivanco Jonathan Waxman Robert M. KyptaThe expression of the secreted factor...
Three-Dimensional Heterostructured Reduced Graphene Oxide-Hexagonal Boron Nitride-Stacking Material for Silicone Thermal Grease with Enhanced Thermally Conductive Properties03:00by Weijie Liang via MDPI PublishingNanomaterials, Vol. 9, Pages 938: Three-Dimensional Heterostructured Reduced Graphene Oxide-Hexagonal Boron Nitride-Stacking Material for Silicone Thermal Grease with Enhanced Thermally Conductive PropertiesNanomaterials doi: 10.3390/nano9070938Authors: Weijie Liang Xin Ge Jianfang Ge Tiehu...
The World Association against Infection in Orthopaedics and Trauma (WAIOT) procedures for Microbiological Sampling and Processing for Periprosthetic Joint Infections (PJIs) and other Implant-Related Infections03:00by Drago via MDPI PublishingJCM, Vol. 8, Pages 933: The World Association against Infection in Orthopaedics and Trauma (WAIOT) procedures for Microbiological Sampling and Processing for Periprosthetic Joint Infections (PJIs) and other Implant-Related InfectionsJournal of Clinical Medicine doi:...
Site-Specific Incorporation of Unnatural Amino Acids into Escherichia coli Recombinant Protein: Methodology Development and Recent Achievement03:00by Smolskaya via MDPI PublishingBiomolecules, Vol. 9, Pages 255: Site-Specific Incorporation of Unnatural Amino Acids into Escherichia coli Recombinant Protein: Methodology Development and Recent AchievementBiomolecules doi: 10.3390/biom9070255Authors: Smolskaya AndreevMore than two decades ago a general method to genetically encode noncanonical or unnatural...
Favorable Outcome in Patients with Pheochromocytoma and Paraganglioma Treated with 177Lu-DOTATATE03:00by Achyut Ram Vyakaranam via MDPI PublishingCancers, Vol. 11, Pages 909: Favorable Outcome in Patients with Pheochromocytoma and Paraganglioma Treated with 177Lu-DOTATATECancers doi: 10.3390/cancers11070909Authors: Achyut Ram Vyakaranam Joakim Crona Olov Norlén Dan Granberg Ulrike Garske-Román Mattias Sandström Katarzyna Fröss-Baron Espen Thiis-Evensen Per Hellman Anders SundinPeptide receptor radiotherapy...
The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism03:00by Marjorie Reyes-Farias via MDPI PublishingIJMS, Vol. 20, Pages 3177: The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer MetabolismInternational Journal of Molecular Sciences doi: 10.3390/ijms20133177Authors: Marjorie Reyes-Farias Catalina Carrasco-PozoCancer is a problem with worldwide importance and is the second leading cause of death globally. Cancer cells reprogram their metabolism to support...
ATP Binding Cassette Transporter A1 is Involved in Extracellular Secretion of Acetylated APE1/Ref-103:00by Yu Ran Lee via MDPI PublishingIJMS, Vol. 20, Pages 3178: ATP Binding Cassette Transporter A1 is Involved in Extracellular Secretion of Acetylated APE1/Ref-1International Journal of Molecular Sciences doi: 10.3390/ijms20133178Authors: Yu Ran Lee Hee Kyoung Joo Eun Ok Lee Hyun Sil Cho Sunga Choi Cuk-Seong Kim Byeong Hwa JeonAcetylation of nuclear apurinic/apyrimidinic endonuclease-1/redox factor-1...
Whole Genome Sequencing of the Blue Tilapia (Oreochromis aureus) Provides a Valuable Genetic Resource for Biomedical Research on Tilapias03:00by Chao Bian via MDPI PublishingMarine Drugs, Vol. 17, Pages 386: Whole Genome Sequencing of the Blue Tilapia (Oreochromis aureus) Provides a Valuable Genetic Resource for Biomedical Research on TilapiasMarine Drugs doi: 10.3390/md17070386Authors: Chao Bian Jia Li Xueqiang Lin Xiyang Chen Yunhai Yi Xinxin You Yiping Zhang Yunyun Lv Qiong ShiBlue tilapia (Oreochromis...
Animal Models for Crimean-Congo Hemorrhagic Fever Human Disease03:00by Garrison via MDPI PublishingViruses, Vol. 11, Pages 590: Animal Models for Crimean-Congo Hemorrhagic Fever Human DiseaseViruses doi: 10.3390/v11070590Authors: Garrison Smith GoldenCrimean-Congo hemorrhagic fever virus (CCHFV) is an important tick-borne human pathogen endemic throughout Asia, Africa and Europe. CCHFV is also an emerging virus, with recent outbreaks in Western Europe. CCHFV can infect a large number of wild and...
The Socio-Linguistic Adaptation of Migrants: The Case of Oralman Students' Studying in Kazakhstan03:00by Valieva via MDPI PublishingEducation Sciences, Vol. 9, Pages 164: The Socio-Linguistic Adaptation of Migrants: The Case of Oralman Students' Studying in KazakhstanEducation Sciences doi: 10.3390/educsci9030164Authors: Valieva Sagimbayeva Kurmanayeva TazhitovaThis article examines different aspects of the oralman students' socio-linguistic adaptation. Scientific research has identified various...
Treatment Options for Colistin Resistant Klebsiella pneumoniae: Present and Future03:00by Petrosillo via MDPI PublishingJCM, Vol. 8, Pages 934: Treatment Options for Colistin Resistant Klebsiella pneumoniae: Present and FutureJournal of Clinical Medicine doi: 10.3390/jcm8070934Authors: Petrosillo Taglietti GranataMultidrug-resistant (MDR) Klebsiella pneumoniae represents an increasing threat to human health, causing difficult-to-treat infections with a high mortality rate. Since colistin is one of...
Frontiers in Psychology ,Effect of a Combined Exercise and Dietary Intervention on Self-Control in Obese AdolescentsObjective: To determine whether a combined exercise and dietary intervention improved cognitive self-control and physical self-control and whether pre-to-post intervention changes in self-control were mediated by changes in body mass index (BMI) and maximal grip strength (MGS), in a sample of obese adolescents. Method: Forty-four obese adolescents were randomly assigned to a 6-week...
Multifaceted Applications of Microbial Pigments: Current Knowledge, Challenges and Future Directions for Public Health Implications03:00by Ramesh via MDPI PublishingMicroorganisms, Vol. 7, Pages 186: Multifaceted Applications of Microbial Pigments: Current Knowledge, Challenges and Future Directions for Public Health ImplicationsMicroorganisms doi: 10.3390/microorganisms7070186Authors: Ramesh Vinithkumar Kirubagaran Venil DufosséMicrobial oddities such as versatile pigments are gaining more attention...
Tanshinone IIA Restores Dynamic Balance of Autophagosome/Autolysosome in Doxorubicin-Induced Cardiotoxicity via Targeting Beclin1/LAMP103:00by Xiaoping Wang via MDPI PublishingCancers, Vol. 11, Pages 910: Tanshinone IIA Restores Dynamic Balance of Autophagosome/Autolysosome in Doxorubicin-Induced Cardiotoxicity via Targeting Beclin1/LAMP1Cancers doi: 10.3390/cancers11070910Authors: Xiaoping Wang Chun Li Qiyan Wang Weili Li Dongqing Guo Xuefeng Zhang Mingyan Shao Xu Chen Lin Ma Qian Zhang Wei Wang...
Management of Glucose Control in Noncritically Ill, Hospitalized Patients Receiving Parenteral and/or Enteral Nutrition: A Systematic Review03:00by Céline Isabelle Laesser via MDPI PublishingJCM, Vol. 8, Pages 935: Management of Glucose Control in Noncritically Ill, Hospitalized Patients Receiving Parenteral and/or Enteral Nutrition: A Systematic ReviewJournal of Clinical Medicine doi: 10.3390/jcm8070935Authors: Céline Isabelle Laesser Paul Cumming Emilie Reber Zeno Stanga Taulant Muka Lia BallyHyperglycemia...
Integrated Computational Analysis Highlights unique miRNA Signatures in the Subventricular Zone and Striatum of GM2 Gangliosidosis Animal Models 03:00by Francesco Morena via MDPI PublishingIJMS, Vol. 20, Pages 3179: Integrated Computational Analysis Highlights unique miRNA Signatures in the Subventricular Zone and Striatum of GM2 Gangliosidosis Animal ModelsInternational Journal of Molecular Sciences doi: 10.3390/ijms20133179Authors: Francesco Morena Vasileios Oikonomou Chiara Argentati Martina Bazzucchi...
Decoding Immune Heterogeneity of Triple Negative Breast Cancer and Its Association with Systemic Inflammation03:00by Romero-Cordoba via MDPI PublishingCancers, Vol. 11, Pages 911: Decoding Immune Heterogeneity of Triple Negative Breast Cancer and Its Association with Systemic InflammationCancers doi: 10.3390/cancers11070911Authors: Romero-Cordoba Meneghini Sant Iorio Sfondrini Paolini Agresti Tagliabue BianchiTriple negative breast cancer (TNBC) is an aggressive subtype with limited therapeutic options....
Genome-Wide Homozygosity Patterns and Evidence for Selection in a Set of European and Near Eastern Horse Breeds03:00by Grilz-Seger via MDPI PublishingGenes, Vol. 10, Pages 491: Genome-Wide Homozygosity Patterns and Evidence for Selection in a Set of European and Near Eastern Horse BreedsGenes doi: 10.3390/genes10070491Authors: Grilz-Seger Neuditschko Ricard Velie Lindgren Mesarič Cotman Horna Dobretsberger Brem DrumlIntensive artificial and natural selection have shaped substantial variation among...
Surface Immobilization of Nano-Silver on Polymeric Medical Devices to Prevent Bacterial Biofilm Formation03:00by Riau via PathogensPathogens, Vol. 8, Pages 93: Surface Immobilization of Nano-Silver on Polymeric Medical Devices to Prevent Bacterial Biofilm FormationPathogens doi: 10.3390/pathogens8030093Authors: Riau Aung Setiawan Yang Yam Beuerman Venkatraman Mehta: Bacterial biofilm on medical devices is difficult to eradicate. Many have capitalized the anti-infective capability of silver ions (Ag+)...
In search of the most cost‐effective monitoring strategy for vestibular schwannoma: A decision analytical modelling studyMirre Scholte Mayke A. Hentschel Gerjon Hannink Henricus P. M. Kunst Stefan C. Steens Maroeska M. Rovers Janneke P. C. GruttersFirst published: 28 March 2019 https://doi.org/10.1111/coa.13326Read the full textePDFPDFTOOLS SHAREAbstractObjectivesTo assess the cost‐effectiveness of frequently used monitoring strategies for vestibular schwannoma (VS).DesignA state transition...
Increased risk of larynx cancer in patients with gastroesophageal reflux disease from a national sample cohortSo Young Kim Bumjung Park Hyun Lim Miyoung Kim Il Gyu Kong Hyo Geun ChoiFirst published: 18 March 2019 https://doi.org/10.1111/coa.13328Kim and Park equally contributed in this studyRead the full textePDFPDFTOOLS SHAREAbstractObjectivesThe present study evaluated the associations between gastroesophageal reflux disease (GERD) and head and neck cancer using a national sample cohort of...
Peak nasal inspiratory flow measurement and visual analogue scale in a large adult populationGiancarlo Ottaviano Alfonso Luca Pendolino Ennio Nardello Pietro Maculan Alessandro Martini Massimiliano Russo Valerie J. LundFirst published: 18 March 2019 https://doi.org/10.1111/coa.13329Read the full textePDFPDFTOOLS SHAREAbstractObjectivesNasal obstruction is the most common symptom in nasal diseases. It can be evaluated objectively, that is by means of peak nasal inspiratory flow (PNIF) measures...
Investigating the nasal cycle using unilateral peak nasal inspiratory flow and acoustic rhinometry minimal cross‐sectional area measurementsMartin Fan Min Tan Katherine Lisa Whitcroft Nishchay Mehta Anne Schilder Terence S. Leung Peter J. AndrewsFirst published: 15 February 2019 https://doi.org/10.1111/coa.13313Read the full textePDFPDFTOOLS SHAREAbstractObjectiveTo plot the nasal cycle using unilateral peak nasal inspiratory flow (UPNIF) and unilateral minimal cross‐sectional area (UMCA) readings...
Cost‐effectiveness of trans‐nasal endoscopic sphenopalatine artery ligation vs arterial embolisation for intractable epistaxis: Long‐term analysesNadège Costa Michael Mounié Geraldine Bernard Laurent Bieler Laurent Molinier Elie Serrano Guillaume de BonnecazeFirst published: 05 February 2019 https://doi.org/10.1111/coa.13299Presented at a meeting: This study was presented at the ‐ IFOS ENT World Congress, 24‐28 June 2017, Paris, FranceRead the full textePDFPDFTOOLS SHAREAbstractObjectivesTrans‐nasal...
Immunity‐targeted approaches to the management of chronic and recurrent upper respiratory tract disorders in childrenWojciech Feleszko Ricardo Marengo Antonio Sousa Vieira Karol Ratajczak José Luis Mayorga ButrónFirst published: 28 March 2019 https://doi.org/10.1111/coa.13335Read the full textePDFPDFTOOLS SHAREAbstractBackgroundUpper respiratory tract infections (URTIs), including rhinitis, nasopharyngitis, tonsillitis and otitis media (OM), comprise of 88% of total respiratory infections, especially...
The Correlation Analysis of Intralabyrinthine Hemorrhage Magnetic Resonance Imaging with Hearing Loss and Prognosis:A Retrospective Analysis of 207 casesClinical Otolaryngology, Volume 0, Issue ja, -Not available-. Evolving management strategies in head and neck paragangliomas: A single‐centre experience with 147 patients over a 60‐year periodClinical Otolaryngology, EarlyView. Functional relevance of Computational Fluid Dynamics in the field of nasal obstruction: a literature reviewClinical Otolaryngology,...
Sialadenitis May Be Associated With an Increased Risk for Osteoradionecrosis: A Nationwide Population-Based Cohort StudyPublication date: July 2019Source: Journal of Oral and Maxillofacial Surgery, Volume 77, Issue 7Author(s): Yi-Fang Huang, Shih-Ping Liu, Chih-Hsin Muo, Chung-Ta Chang, Chun-Hao Tsai, Donald E. MoriskyPurposeThe impact of sialadenitis on osteoradionecrosis (ORN) is controversial. The aim of this study was to determine the association between sialadenitis and ORN.Materials and MethodsParticipants...
The Anesthetic Management of a Cardiac Transplant Patient Following Extensive Facial Trauma Caused by a Pit Bull AttackA 72-year-old male cardiac transplant patient presented after sustaining facial and extremity trauma caused by a pit bull dog attack. The case was further complicated by duration of the surgery, bleeding, infection risk, intraoperative hypothermia, immunosuppression, and the risk of sepsis. His anesthetic management required careful coordination with his transplant team. We also...
Comment on "Investigation of an Opioid Prescribing Protocol After Third Molar Extraction Procedures"Full TextReferencesPDF (86 KB)Email ArticleAdd to My Reading ListExport CitationCreate Citation AlertCited by in Scopus (0)Request PermissionsOrder Reprints(100 minimum order)Brent L. Florine, DDSEagan, MNJournal of Oral and Maxillofacial Surgery, Volume 77, Issue 7Published online: April 20, 2019DOI: https://doi.org/10.1016/j.joms.2019.03.027 | Substantial change to deeply ingrained and long-standing...
Validation of targeted microsurgical spermatic cord denervation: comparison of outcomes to traditional complete microsurgical spermatic cord denervationParviz K KavoussiAsian Journal of Andrology 2019 21(4):319-323The aim of this study was to validate the effectiveness of targeted microsurgical spermatic cord denervation (MSCD) of the trifecta nerve complex in comparison to traditional full MSCD with complete skeletonization of the spermatic cord in men with chronic orchialgia. Retrospective chart...
Quantitative Electroencephalogram Trends Predict Recovery in Hypoxic-Ischemic EncephalopathyObjectives: Electroencephalogram features predict neurologic recovery following cardiac arrest. Recent work has shown that prognostic implications of some key electroencephalogram features change over time. We explore whether time dependence exists for an expanded selection of quantitative electroencephalogram features and whether accounting for this time dependence enables better prognostic predictions. Design:...
It's a doc's life – Workplace violence against doctorsMrittika Sen, Santosh G HonavarIndian Journal of Ophthalmology 2019 67(7):981-984Machine learning in clinical care: Quo vadis?Vasant G HonavarIndian Journal of Ophthalmology 2019 67(7):985-986The second time aroundLi‐Anne L Lim, Md K Hasanuzzaman, Carol L ShieldsIndian Journal of Ophthalmology 2019 67(7):987-987Robotics and ophthalmology: Are we there yet?Suresh K Pandey, Vidushi SharmaIndian Journal of Ophthalmology 2019 67(7):988-994Ophthalmology...
Association of serum Sestrin-2 level with insulin resistance, metabolic syndrome, and diabetic nephropathy in patients with type 2 diabetesHazem M EL-Ashmawy, Azza M AhmedThe Egyptian Journal of Internal Medicine 2019 31(2):107-114Background The aim of the study was to evaluate the relationship between serum Sestrin2, Insulin resistance (IR), metabolic syndrome (MetS), and diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM). Patients and methods The study group consisted of...
UntitledΑΛΕΞΑΝΔΡΟΣ Γ. ΣΦΑΚΙΑΝΑΚΗΣ at Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174 - 11 minutes agoPreclinical findings on the potential of intranasal neuropeptide Y for treating hyperarousal features of PTSD Thu Jun 27, 2019 21:13 by Chiso Nwokafor, Lidia I. Serova, Esther L. Sabban via Annals of the New York Academy of Sciences [image: Annals of the New York Academy of Sciences Preclinical findings on the potential of intranasal neuropeptide...
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,