Why treatment efficacy on breathlessness in laboratory but not daily life trials? The importance of standardized exertionPurpose of review Treatments for chronic breathlessness, including opioids and oxygen, have shown efficacy in the controlled laboratory setting, whereas effects have been inconsistent or absent in trials in daily life. This review discusses the lack of standardized exertion as a potential cause of false negative findings for breathlessness in daily life. Recent findings The level...
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Quality of life after pancreas transplantation: time to look againPurpose of review To summarize the existing body of literature regarding quality of life after pancreas transplantation, discuss the limitations of existing studies and make an argument for the need for future investigation on this important topic using standard verifiable instruments and utility measurements. Recent findings Reinvigorating support for pancreas transplantation as a life-extending and quality-of-life-enhancing treatment...
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Prediction Model for Audiological Outcomes in Patients With GJB2 MutationsObjectives: Recessive mutations in GJB2 are the most common genetic cause of sensorineural hearing impairment (SNHI) in humans. SNHI related to GJB2 mutations demonstrates a wide variation in audiological features, and there has been no reliable prediction model for hearing outcomes until now. The objectives of this study were to clarify the predominant factors determining hearing outcome and to establish a predictive model...
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Cancer Biotherapy and RadiophamaceuticalsOriginal ArticlesDesign, Synthesis, Radiolabeling, and Biologic Evaluation of Three 18F-FDG-Radiolabeled Targeting Peptides for the Imaging of ApoptosisSepideh Khoshbakht, Davood Beiki, Parham Geramifar, Farzad Kobarfard, Omid Sabzevari, Mohsen Amini, Noushin Bolourchian, Danial Shamshirian, and Soraya ShahhosseiniPages:271–279Published Online:4 March 2019https://doi.org/10.1089/cbr.2018.2709AbstractFull textPDFSupplemental MaterialsPermissionsPreview AbstractAbstract Background: Early...
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Resection of Septal Adenoid Cystic Carcinoma and Primary Reconstruction of the Surgical Defect via Open RhinoplastyAdenoid cystic carcinoma is one of the most common minor salivary gland malignancies of the head and neck region. However, adenoid cystic carcinoma of the nasal septum is extremely rare. The authors herein report a case of a septal adenoid cystic carcinoma in a 68-year-old man who complained of nasal bleeding and nasal obstruction for several months. Diagnostic nasal endoscopy revealed...
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Directory: AAO Officers and OrganizationsPublication date: June 2019Source: American Journal of Orthodontics and Dentofacial Orthopedics, Volume 155, Issue 6Author(s):Craniofacial embryogenetics and developmentPublication date: June 2019Source: American Journal of Orthodontics and Dentofacial Orthopedics, Volume 155, Issue 6Author(s): David S. CarlsonJune 2019:155(6)Publication date: June 2019Source: American Journal of Orthodontics and Dentofacial Orthopedics, Volume 155, Issue 6Author(s): Dr Allen...
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Original ResearchCardiac CT Prognosis of CT-derived Fractional Flow Reserve in the Prediction of Clinical Outcomes In this single-center real-world experience of intermediate-term outcomes, it was demonstrated that at a median follow-up of more than 1 year, a positive result at fractional flow reserve (FFR) derived from CT (or FFRCT) analysis was associated with a significantly increased risk of late revascularization and myocardial infarction. Charis G. McNabney, Stephanie L. Sellers... Jonathan...
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18F-FDG PET/CT in Oral Cuniculatum CarcinomaA 69-year-old woman was referred for initial staging of an oral cavity mass. 18F-FDG PET/CT displayed a homogeneous intense uptake of the 50-mm left hemipalatal mass with local extension to the dental arcade and maxillary sinus. Infracentimetric bilateral cervical nodes with faint uptake were also detected, contrasting with the usual presentation of other head and neck squamous cell carcinoma. Biopsy concluded to a rare head and neck squamous cell carcinoma...
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The Base Deficit, International Normalized Ratio, and Glasgow Coma Scale (BIG) Score, and Functional Outcome at Hospital Discharge in Children With Traumatic Brain InjuryObjectives: To examine the association of the base deficit, international normalized ratio, and Glasgow Coma Scale (BIG) score on emergency department arrival with functional dependence at hospital discharge (Pediatric Cerebral Performance Category ≥ 4) in pediatric multiple trauma patients with traumatic brain injury. Design: A...
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: A report of rare entityR Dibin, Sibi Joseph, T Muhammad Ali, PK AlshakhirDepartment of Oral and Maxillofacial Surgery, Government Dental College, Kottayam, Kerala, IndiaCorrespondence Address:Dr. R DibinDepartment of Oral and Maxillofacial Surgery, Government Dental College, Gandhinagar, Kottayam - 686 008, Kerala IndiaCheckDOI: 10.4103/jss.JSS_46_18 Abstract Adenosquamous carcinoma of the head and neck (ADSC) is a rare and aggressive variant of squamous cell carcinoma (SCC), a locally aggressive...
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Audio-visual consent process in clinical researchJayaprakash S AppajigolJournal of the Scientific Society 2018 45(3):111-112Laparoscopic-assisted percutaneous nephrolithotomy in ectopic kidneyShreyas Bhadranavar, RB Nerli, Shridhar C Ghagane, Murigendra B HiremathJournal of the Scientific Society 2018 45(3):113-115Renal calculi pose challenges to the health of a person with a normal anatomically positioned kidney. If renal stones occur in a pelvic ectopic kidney, then the health risk it poses is...
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Kazuhiro Ueda, Atsushi Kiyota, Mariko Tsuchida, Mikako Okazaki, Nobuaki OzakiAuthor informationKeywords: Levothyroxine, Liothyronine, Myxedema comaJOURNALS FREE ACCESS FULL-TEXT HTML2019 Volume 66 Issue 5 Pages 469-474DOI https://doi.org/10.1507/endocrj.EJ18-0469Browse "Advance Publication" version.DetailsFull Text-HTMLDownload PDF (1687K)Download MetaRIS(compatible with EndNote, Reference Manager, ProCite, RefWorks)BIB TEX(compatible with BibDesk, LaTeX) TextHow to download MetaContact usArticle...
Thu Jun 27, 2019 16:51
ORIGINAL ARTICLEPrognostic implications of residual disease tumor-infiltrating lymphocytes and residual cancer burden in triple-negative breast cancer patients after neoadjuvant chemotherapyNeoadjuvant chemotherapy (NAC) is a commonly utilized strategy for the treatment of early-stage triple-negative breast cancer (TNBC). A major advantage of this strategy is the ability to observe the tumor response to chemotherapy. Pathologic complete response (pCR) is a well-established end point of NAC clinical...
Thu Jun 27, 2019 16:46
Highly cited articlesOriginal researchDe-escalating and escalating treatments for early-stage breast cancer: the St. Gallen International Expert Consensus Conference on the Primary Therapy of Early Breast Cancer 2017G Curigliano, H J Burstein, E P Winer, et al.3rd ESO–ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 3)F. Cardoso, A. Costa, E. Senkus, et al.Anti-PD-1 therapy in patients with advanced melanoma and preexisting autoimmune disorders or major toxicity with ipilimumabA....
Thu Jun 27, 2019 16:45
Quantitative Electroencephalogram Trends Predict Recovery in Hypoxic-Ischemic EncephalopathyObjectives: Electroencephalogram features predict neurologic recovery following cardiac arrest. Recent work has shown that prognostic implications of some key electroencephalogram features change over time. We explore whether time dependence exists for an expanded selection of quantitative electroencephalogram features and whether accounting for this time dependence enables better prognostic predictions. Design:...
Thu Jun 27, 2019 16:43
Expression profile of circular RNAs in placentas of women with gestational diabetes mellitus Huiyan...Expression profile of circular RNAs in placentas of women with gestational diabetes mellitusHuiyan Wang, Guangtong She, Wenbai Zhou, Kezhuo Liu, Jun Miao, Bin YuAuthor informationKeywords: Gestational diabetes mellitus, CircRNA, RNA sequencing, MicroRNA, PlacentaJOURNALS FREE ACCESS FULL-TEXT HTML2019 Volume 66 Issue 5 Pages 431-441DOI https://doi.org/10.1507/endocrj.EJ18-0291Browse "Advance Publication"...
Thu Jun 27, 2019 16:41
Constraint-induced Movement Therapy for improving motor function of the paretic lower extremity after stroke: a case reportA 56-year-old woman with chronic stroke and gait dysfunction was recruited for this study. A Lower-Extremity Constraint-Induced Movement Therapy (LE-CIMT) protocol was given consisting of 3.5 hours/day of supervised intervention activities on 10 consecutive weekdays. Motor training was intensive and involved shaping. In addition, a group of behavior management strategies was...
Thu Jun 27, 2019 14:56
Revisit epoch duration for sake of patient-friendly sleep studiesSignificance of early morning insomnia for keeping the work continuity of shift workersRelationship with excessive daytime sleepiness and serum substance P levels in OSAS patients and the effect of PAP treatmentAbstractObstructive sleep apnea syndrome (OSAS) is a commonly seen disorder characterized by repeated episodes of upper airway obstruction during sleep leading to intermittent hypoxemia or arousal. We aim to evaluate the effects...
Thu Jun 27, 2019 14:54
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,