Site‐Resolved Observation of Vibrational Energy Transfer Using a Genetically Encoded Ultrafast Heater

Vibrational energy transfer (VET) in proteins has been linked to allostery and other aspects of protein function in computational studies. In their Communication (DOI: 10.1002/anie.201812995), J. Bredenbeck, N. Budisa, and co‐workers show how vibrational energy can be injected and tracked experimentally in a site‐selective way. By using a genetically encoded ultrafast heater and femtosecond IR spectroscopy, this approach allowed them to map out VET pathways in proteins and to explore the role of VET for protein function.

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