Subcutaneous Administration of PDGF-AA Improves the Functional Recovery After Spinal Cord Injury.

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Subcutaneous Administration of PDGF-AA Improves the Functional Recovery After Spinal Cord Injury.

Front Neurosci. 2019;13:6

Authors: Guo XY, Duan FX, Chen J, Wang Y, Wang R, Shen L, Qi Q, Jiang ZQ, Zhu AY, Xi J, Lü HZ, Hu JG

Abstract
Previous studies by our group have demonstrated that the transplantation of exogenous platelet-derived growth factor (PDGF)-AA-overexpressing oligodendrocyte progenitor cells (OPCs) promotes tissue repair and recovery of neurological function in a rat model of spinal cord injury (SCI). However, it remains unclear whether treatment with PDGF-AA also affects endogenous oligodendrocytes (OLs) or even neurons, thus promoting further functional recovery after SCI. In the present study, we evaluated the therapeutic potential of PDGF-AA treatment by direct subcutaneous injection of PDGF-AA immediately after SCI. We demonstrated that PDGF-AA injection resulted in increased tissue sparing, myelination and functional recovery in rats following SCI. Further experimentation confirmed that PDGF-AA increased the survival of endogenous OPCs and OLs, and promoted the proliferation of OPCs and their differentiation into OLs. Moreover, PDGF-AA also protected motor neurons from death in the injured spinal cord. These results indicated that PDGF-AA administration may be an effective treatment for SCI.

PMID: 30723394 [PubMed]

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