Mosaic deletion patterns of the human antibody heavy chain gene locus shown by Bayesian haplotyping

Mosaic deletion patterns of the human antibody heavy chain gene locus shown by Bayesian haplotyping

Mosaic deletion patterns of the human antibody heavy chain gene locus shown by Bayesian haplotyping, Published online: 07 February 2019; doi:10.1038/s41467-019-08489-3

High-throughput sequencing and analyzes of antibody repertoire provide important information on immune responses, but current methodologies are limited in sequence assembly precision and haplotype inference validity. Here the authors propose a new Bayesian haplotyping method, and attest its broad application with a large, multi-individual dataset.

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