Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation

Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation

Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation, Published online: 01 February 2019; doi:10.1038/s41467-019-08404-w

A chromatin remodelling factor Satb1 is essential for T cell lineage development in the thymus. Here the authors show that while Satb1 is dispensable for the differentiation of Th17 cells and their response to gut commensals, it plays a critical role in pathogenic Th17 effector function in EAE by directly activating Bhlhe40 and modulating PD-1.

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