‘Druggable Target’ for Treating Alzheimer’s Discovered

To date, results have been mixed. In a new paper, published in Cell Stem Cell, researchers at the University of California San Diego School of Medicine, in collaboration with colleagues in San Diego and The Netherlands, focused on the alternative therapeutic target: tau. Using induced pluripotent stem cell-derived (iPSC) neurons from AD patients, the researchers report that cholesteryl esters (CE)— the storage product for excess cholesterol within cells— act as regulators of tau. Import...

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