Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer

Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer

Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer, Published online: 15 February 2019; doi:10.1038/s41467-019-08595-2

Triple negative breast cancers (TNBC) disseminate and metastasise, but the clonal relationship of metastases to primary tumours is poorly understood. Here, the authors use cellular barcoding of TNBC patient-derived xenografts and track the fate of barcoded clones in primary tumours and their metastases, including after resection or chemotherapy.

from A via a.sfakia on Inoreader https://go.nature.com/2Ipi3iq