TCR microclusters form spatially segregated domains and sequentially assemble in calcium-dependent kinetic steps

TCR microclusters form spatially segregated domains and sequentially assemble in calcium-dependent kinetic steps

TCR microclusters form spatially segregated domains and sequentially assemble in calcium-dependent kinetic steps, Published online: 17 January 2019; doi:10.1038/s41467-018-08064-2

Engagement of T cell receptors (TCRs) induces the formation of microclusters that mediate the downstream signalling events. Here the authors show, using high resolution TIRF-SIM and live cell imaging, that ZAP70 and LAT are recruited to TCR with distinct kinetics, with the delayed ZAP70-TCR association modulated by TCR-induced calcium flux.

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