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Τετάρτη 23 Ιανουαρίου 2019

Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues

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Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues

Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues, Published online: 23 January 2019; doi:10.1038/s41467-019-08296-w

The DNA ligase of African swine fever virus is one of the most error-prone ligases identified to date, but underlying molecular details are lacking. Here, Chen et al. report four AsfvLIG:DNA structures and identify a unique N-terminal domain and four unique active site residues that are crucial for its catalytic efficiency.

from A via a.sfakia on Inoreader https://go.nature.com/2S4RXoL

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,

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