Single‐Atom Nanozyme for Wound Antibacterial Applications

The single‐atom catalysts (SACs) as homogeneous catalysts have been widely explored for chemical catalysis. However, few studies focus on SACs' applications in enzymatic catalysis. Herein, we first report that a zinc‐based zeolitic−imidazolate‐frameworks (ZIF‐8) derived carbon nanomaterial containing atomically dispersed zinc atoms could serve as a highly efficient single‐atom peroxidase mimic. To reveal its structure‐activity relationship, we systematically investigated the structural evolution of SAzyme. In addition, the coordinatively unsaturated active zinc sites and catalytic mechanism of SAzyme are disclosed using density functional theory (DFT) calculations. The SAzyme with high therapeutic effect and biosafety shows great promises for wound antibacterial applications.

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