Photoredox‐Coupled F‐Nucleophilic‐Addition‐Induced Allylation of gem‐Difluoroalkenes

A novel strategy for the expedient construction of CF3‐embeded tertiary/quarternary carbon centers is developed by taking advantage of photoredox catalysis. Thanks to a key step of single electron oxidation, electron‐rich gem‐difluoroalkenes, which otherwise are essentially reluctant towards F‐nucleoplilic addition, now readily participate in this fluoroallylation reaction. Furthermore, this strategy provides an elegant example for the generation as well as functionalization of α‐CF3‐substituted benzylic radical intermediates using cheap and readily available starting materials.

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