Late‐Stage Diversification through Manganese‐Catalyzed C−H Activation: Access to Acyclic, Hybrid, and Stapled Peptides

Sustainable manganese(I) catalysis enables versatile late‐stage modifications of peptides, nucleotides, and drugs to give hybrid compounds with broad functional‐group tolerance and ample scope.

Abstract

Bioorthogonal C−H allylation with ample scope was accomplished through a versatile manganese(I)‐catalyzed C−H activation for the late‐stage diversification of structurally complex peptides. The unique robustness of the manganese(I) catalysis manifold was reflected by full tolerance of sensitive functional groups, such as iodides, esters, amides, and OH‐free hydroxy groups, thereby setting the stage for the racemization‐free synthesis of C−H fused peptide hybrids featuring steroids, drug molecules, natural products, nucleobases, and saccharides.

from A via a.sfakia on Inoreader http://bit.ly/2Wq8iUd