Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity

Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity

Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity, Published online: 16 January 2019; doi:10.1038/s41467-018-08231-5

Deubiquitinating enzymes (DUBs) are critical regulators of cellular processes by removing ubiquitin from specific targets. Here global kinetic modelling reveals the mechanism by which the low intrinsic activity of USP7 is substantially enhanced on a specific physiological target.

from A via a.sfakia on Inoreader https://go.nature.com/2Hfjdga