Contributions of innate lymphocytes to allergic responses

Purpose of review Allergic diseases represent a growing global health concern, especially among pediatric populations. Current strategies for the treatment of allergies and asthma focus on limiting the severity of the symptoms; however, additional research investigating the mechanisms promoting inflammation in the context of allergic reactions may lead to the development of more effective therapeutic strategies. Recent findings Novel studies have highlighted the contributions of innate lymphocytes to the induction of inflammatory responses to allergens. Remarkably, neuron-derived signals, hormones, and even vitamins have been suggested to modulate the activity of innate lymphocytes, opening new windows of opportunity for the treatment of allergic inflammation. Summary These studies highlight the complex interactions of the nervous, endocrine, and immune system that promote pathology in the context of allergic inflammation. Further studies are required to understand these interactions in order to aid in the development of novel and much-needed therapies to treat allergic conditions. Correspondence to Mark C. Siracusa, Department of Medicine Cancer Center, G1226 Rutgers New Jersey Medical School 205 South Orange Avenue, Newark, NJ 07103, USA. Tel: +1-973-972-1265; fax: +1-973-972-2525; e-mail: mark.siracusa@rutgers.edu Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

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