Assembling a Hybrid Pd Catalyst from a Chiral Anionic CoIII Complex and Ligand for Asymmetric C(sp3)–H Functionalization

A hybrid chiral palladium catalyst for the asymmetric arylation of saturated aza‐heterocycles is described by X. Zhang, L.‐Z. Gong, and co‐workers in their Communication (DOI: 10.1002/anie.201812426). The demonstrated hybrid catalyst consists of a chiral phosphoramidite ligand and a chiral Co^III‐based counteranion. It exhibits a high capacity for catalyzing asymmetric thioamide‐directed C(sp³)–H arylation and offers excellent yield and enantioselectivity (up to 99% yield, 99% ee).

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