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Τρίτη 15 Ιανουαρίου 2019

Achiral Trisubstituted Thioureas as Secondary Ligands to CuI Catalysts: Direct Catalytic Asymmetric Addition of α‐Fluoronitriles to Imines

Angewandte Chemie International Edition Achiral Trisubstituted Thioureas as Secondary Ligands to CuI Catalysts: Direct Catalytic Asymmetric Addition of α‐Fluoronitriles to Imines

Thioureas, which are popular hydrogen‐bonding donors in organocatalysis, are revealed to act as Lewis basic ancillary ligands in CuI catalysis by N. Kumagai, M. Shibasaki, and co‐workers in their Communication (DOI: 10.1002/anie.201812673). Achiral trisubstituted thioureas played an indispensable role in controlling the stereochemical course of the CuI‐catalyzed direct coupling reaction of α‐fluorinated nitriles and aldimines, delivering densely functionalized chiral building blocks.




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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,

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