Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin

Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin

Regulation of mycobacterial infection by macrophage <i>Gch1</i> and tetrahydrobiopterin, Published online: 20 December 2018; doi:10.1038/s41467-018-07714-9

Inducible nitric oxide (NO) synthase (iNOS) is essential in the response to mycobacterial infection, yet NOS signalling can occur through NO-dependent or NO-independent pathways. Here the authors show macrophage Gch1 and tetrahydrobiopterin mediate NO-independent control of Mycobacterial infection.

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